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Glyceraldehyde-3-phosphate dehydrogenase (NADP+) : ウィキペディア英語版 | Glyceraldehyde-3-phosphate dehydrogenase (NADP+)
Glyceraldehyde-3-phosphate dehydrogenase (NADP+) () (GAPN) is an enzyme that irreversibly catalyzes the oxidation of glyceraldehyde-3-phosphate (GAP) to 3-phosphoglycerate (3-PG or 3-PGA) using the reduction of NADP+ to NADPH. GAPN is used in a variant of glycolysis that conserves energy as NADPH rather than as ATP. The NADPH and 3-PG can then be used for synthesis. The most familiar variant of glycolysis uses glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoglycerate kinase to produce ATP. GAPDH is phosphorylating. GAPN is non-phosphorylating. GAPN was reported first by Rosenberg and Arnon in 1954.〔 It has been found in plants, algae, and bacteria.〔 ==Reactions== Glyceraldehyde-3-phosphate dehydrogenase (NADP+) catalyzes :GAP + NADP+ + H2O → 3-PG + NADPH + H+ Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase catalyze :GAP + NAD+ + Pi 1,3-bisphosphoglycerate + NADH + H+ :1,3-bisphosphoglycerate + ADP 3-PG + ATP Usually () / () >> 1 >> () / ().
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